Thiocodin® Syrup (Codeine Phosphate + Terpin Hydrate)Thiocodin, 15 mg + 300
Prescription Medicine – Keep out of reach of children
Composition (per 10 ml):
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Codeine phosphate hemihydrate 15 mg
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Terpin hydrate 300 mg
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Alcohol content: [X]% v/v (specify if known)
Therapeutic Category:
Antitussive + Expectorant combination
Clinical Pharmacology
1. Codeine Phosphate:
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Opioid antitussive that suppresses the cough reflex center
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Onset: 30-45 minutes | Duration: 4-6 hours
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Metabolized to morphine (CYP2D6 pathway)
2. Terpin Hydrate:
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Secretolytic agent enhances bronchial secretions
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Demonstrates mild antiseptic properties
Indications & Usage
✅ Approved Uses:
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Temporary relief of unproductive dry cough
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Symptomatic treatment of irritating cough
⚠ Important Limitations:
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Not for chronic cough without medical supervision
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Contraindicated in productive cough
Dosage (Adults & Adolescents ≥12 years):
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5-10 ml every 4-6 hours
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Maximum: 40 ml/24 hours
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Duration: ≤5 days unless directed
Administration:
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Use graduated measuring cup
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May dilute with water if needed
Safety Information
🔴 Black Box Warning (US):
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Risk of addiction, abuse, and misuse
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Life-threatening respiratory depression
Contraindications:
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Respiratory depression
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Asthma/COPD exacerbations
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Concurrent MAOIs
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Pregnancy (category C)
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Children <12 years
Drug Interactions:
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Potentiates CNS depressants (alcohol, benzodiazepines)
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Serotonin syndrome risk with SSRIs
Adverse Effects:
▸ Constipation (30%)
▸ Drowsiness (25%)
▸ Nausea (15%)
Pharmaceutical Data
Presentation:
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Amber glass bottle (100 ml)
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Child-resistant cap
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Measuring cup included
Storage:
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Below 25°C
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Protect from light
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Shelf life: [X] months after opening
Regulatory Status:
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Rx-only in most jurisdictions
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Controlled substance (Schedule V)
Patient Counseling
💡 Key Instructions:
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Do not exceed recommended dose
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Avoid alcohol and sedatives
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Report breathing difficulties immediately
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Dispose of unused medication properly
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